Kristine Jepson has appeared in leading theaters internationally including the Metropolitan Opera, Teatro alla Scala, Royal Opera, Covent Garden, Theatre Royale de la Monnaie, Opera National de Paris, Royal Opera, Covent Garden, Bavarian State Opera, Hamburg State Opera, Flemish Opera, San Francisco Opera. Canadian Opera Company, Miami Opera, Santa Fe Opera Festival and many others. Jepson has won special acclaim for roles such as Sesto in Mozart's La Clemenza di Tito, the Composer in Strauss's Ariadne auf Naxos and, Sister Helen in Dead Man Walking. In December of 2000 Jepson sang her first performances as Octavian in Der Rosenkavalier at the Metropolitan Opera and was praised highly for her interpretation of this cornerstone of the mezzo repertoire. She has since made her debuts at the Teatro alla Scala, Theatre de La Monnaie in Brussels, the Hamburg State Opera and Bavarian State Opera in Munich all as Octavian.

Kristine Jepson began the 2008/2009 season as Mere Marie in Dialogues des Carmelites in Oviedo before returning to Covent Garden as Nicklausse in Les Contes D’Hoffmann. Ms. Jepson will join the Detroit Symphony Orchestra conducted by James Conlon for Das Lied von der Erde, as well as the Madison Symphony for Verdi’s Requiem. She will sing her first performances of Brangäne in Tristan und Isolde at Deutsche Oper Berlin in spring 2009, and subsequently sings the same role in summer 2009 for her debut at Glyndebourne.